Ascent Prototype

EzerSonic® SoniEV™
Gen1 Isolator

Our cutting-edge EzerSonic® SoniEV™ sEV Isolation Service using SoniEV™ Gen1 Isolator is developed to overcome the limitations of traditional methods, enabling you to breakthrough discoveries.

Powered by our proprietary and patented Acoustofluidics (fusion of Acoustics and Microfluidics) technology platform developed in Penn State University and Duke University.

What are the
Problems?

We understand that academic and industry researchers working with sEVs /exosomes face significant challenges in obtaining high-quality, reliable EV preparations – a critical prerequisite for unlocking the vast potential of these fascinating nanoparticles for diagnosis and therapeutics.

what is the problem

Isolation and Purification

Isolating and purifying extracellular vesicles (EVs) from complex biological fluids like blood and urine is challenging due to their presence among other molecules and contaminants. Current techniques like ultracentrifugation and size-exclusion chromatography are often time-consuming, labor-intensive, and can result in low yields or damage to the EVs.

Standardization

The lack of standardized protocols for EV isolation, characterization, and analysis hinders the reproducibility of results and the comparison of data across different studies and laboratories.

Scalability

Producing large quantities of EVs with consistent quality and purity for clinical or commercial applications is a significant hurdle, as current production methods are often limited in scale and yield.

What is the
Solution?

EzerSonic® SoniEV™ sEV Isolation

Researchers in the field of EVs have long awaited an isolation solution that combines the advantages of gentle handling, high yield, scalability and repeatability.

Acoustofluidic isolation revolutionizes extracellular vesicle (EV) research, offering a scalable and standardized approach for the isolation and purification of EVs, and providing a reliable solution to the challenges posed by traditional techniques in diagnostics and therapeutics.

High yield

High Yield

Up to 20-fold higher EV yields compared to conventional methods

1x input, 1.4x output

Limited -dilutive processing to preserve natural EV composition and integrity

1x input, 1.4x output (PBS as safe biological buffer)

Versatile sample processing volumes

Versatile sample processing volumes

As low as 50ul, no upper limit

Maintain sEV integrity

Maintain sEV integrity

Acoustic handling, a gentle, label-free, and marker-free approach, ensures the EV’s composition and integrity.

Unmatched repeatability and reproducibility for consistent, reliable results

Unmatched repeatability and reproducibility for consistent, reliable results

Correlation between two operators on two instruments > 0.99 for all samples

solutions

WHY CHOOSE EZERSONIC® SONIEV™ sEV ISOLATION SERVICE?

Our World-Leading sEV isolation Service

We offer specialized sample preparation services tailored for many applications in research, personalized medicine, diagnostics, and therapeutics. Our expertise in handling EVs enables us to provide clients with isolated sEV samples that are pivotal for advancing scientific discoveries and enhancing patient care.

Immediate accessibility

Immediate accessibility

No need to invest in expensive capital equipment

Optional EV Characterization

Optional Add-on EV Characterization

Option to choose add-on Nanoparticle Tracking Analysis (NTA), western blot services to gain valuable insights into EV size, concentration, and distribution

Tailored Solutions

Tailored Solutions

Collaborative approach to understand your unique research goals
Customized design with pilot run to meet your research requirements

Simplified Workflows

Simplified Workflows

Simply ship your samples, and we will handle the rest.
Consistent, reliable, and streamlined results

Customer Satisfaction Guaranteed

Customer Satisfaction Guaranteed

We stand behind the quality of our EV Isolation Service
Full refund if not completely satisfied
Your precious samples are in good hands

Free Trial

Free Trial

Experience our service with no risk, free initial sample isolation trials.
Witness the unparalleled results firsthand before committing.

Enabling
Breakthroughs.

We have developed several acoustofluidic methods that have the ability to isolate analytes in a precise, biocompatible, rapid, high-yield, high-purity, label-free, and point-of-care manner. These approaches show great potential as liquid biopsy platforms for performing early-stage disease diagnostics.

How Does it work?

Experience Superiority in EV Isolation

EzerSonic® SoniEV™ sEV Isolation Service streamlines complex scientific endeavors into a clear and concise workflow, ensuring client engagement and success from start to finish, as outlined in these four steps:

1

Customer Inquiry

Receive and evaluate the project request

2

Project Scope

Detail and define project parameters in a collaborative meeting.

3

Pilot Execution

Perform a trial run to validate and refine methodologies.

4

Delivery & Feedback

Provide the final product and gather customer feedback to ensure satisfaction.

Sign Up for a Free Trial of Our Cutting-Edge
Service for Unmatched Research Advancements.

Collaboration case studies

Enabling Breakthroughs

We have collaborated with many partners and conducted extensive case studies, showcasing the effectiveness of our sEV isolation technology. These studies consistently demonstrate that our approach not only surpasses traditional methods in efficiency but also sets a new standard for the field.

Technology Comparison

Several methods are commonly employed for EV isolation, each with its advantages and disadvantages, including associated costs. The selection of an EV isolation method for research hinges on factors like minimum volume, desired purity, yield, available reagents, throughput, and budget, often requiring a mix of methods for best results, with costs balanced against the research goals and the benefits of EVs for further applications. Here’s an analysis of the pros and cons of some common EV isolation methods for research:

METHOD

PROS

CONS

COST

Acoustofluidic

High yield (up to 20X) and maintains EV integrity
Limited dilution, label and marker-free
Versatile for various sample volumes (as little as 50ul)
Unmatched repeatability and consistency
Service available in USA with guaranteed satisfaction and free trial
Customized with optional add-on characterization services

Newly offered commercial service based on proven world leading research
Service currently only available in USA

Moderate to high

Ultracentrifugation

Widely used and established
Separates EVs based on size and density
Can be combined with density gradient media

Low yield
Time-consuming
Operator dependent, requires significant training
Potential for sample loss and degradation
Requires expensive ultracentrifuge equipment
May affect EV integrity

Moderate to high

Size Exclusion Chromatography (SEC)

Gentle method
Separates EVs based on size
Can be combined with other techniques

Limited resolution for separating EVs from similar-sized particles
Potential for sample dilution and loss
Requires specialized equipment and consumables

Moderate to high

Immunoaffinity Capture

Highly specific and selective
Can isolate specific EV subpopulations
Preserves EV integrity

Requires prior knowledge of EV surface markers and specific antibodies
Potential for non-specific binding and loss
Expensive reagents (antibodies) required
Potential to introduce contamination and affect EV integrity

High

Polymer-based Precipitation

Simple and straightforward method
Suitable for large-scale isolation
Generally low cost

Limited specificity
Potential contamination with non-EV particles or polymer reagents
May affect EV integrity

Low to Moderate

EzerSonic® SoniEV™ Gen1 Isolator

The SoniEV™ Gen1 Isolator is designed to transcend traditional method constraints, enabling you to expedite your research and catalyze significant breakthroughs.

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