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NIH Rigor and Reproducibility Study

Goal

GOAL

Validate the Rigor& Reproducibility of the Exosome isolation using acoustofluidic method.

Problem

PROBLEM

Widely used conventional isolation method ultracentrifuge is operator dependent, thus lacks of standardization and repeatability.

What we do

WHAT WE DID

Isolate 10 saliva samples with 2 operators using our instrument

Sample type: Saliva

Case Study

01

Results

Results

Results presented and shared at NIH ERCC19 conference hosted April, 2023,
Correlation between two operators： 0.98 for total sEV number 0.99 for tetraspanins (CD9, CD63, CD81) positive sEV number. (The closer to 1 the better)

NIH Rigor & Reproducibility study

The Extracellular RNA Communication Consortium (ERCC) is an NIH Common Fund program launched in 2013 to study extracellular RNA (exRNA)
https://exrna.org/ercc19/

Research collaborators:

David T. Wong, UCLA
Louise C. Laurent, UCSD
John P. Nolan, Scintillon Institute
Tony Jun Huang, Duke University

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